In today’s world, where many of us are trying to stay sharp, energized, and youthful well into our later years, NAD+ (nicotinamide adenine dinucleotide) has become one of the most exciting molecules in wellness science. If you’ve been exploring ways to boost your metabolism, improve brain function, or simply age more gracefully, there’s a good chance you’ve come across NAD+ supplements—and for good reason.
NAD+ is vital for our survival. It’s involved in almost every major biological process, including energy production, DNA repair, immune defense, and regulating our circadian rhythms. Unfortunately, our NAD+ levels decline naturally with age. Stress, poor sleep, and diet only make it worse. That’s where supplementation comes in—and it’s changing the way we think about aging and performance.
We spent hours researching, reading reviews, comparing ingredient transparency, and analyzing scientific backing to find the 8 best NAD+ supplements in 2025. These aren’t just trendy pills—they’re backed by real science and trusted by experts, athletes, and longevity enthusiasts alike.
🥇 1. Tru Niagen®
Best For: Clinically proven NAD+ support
- Key Ingredient: Nicotinamide Riboside (NR)
- Dose: 300mg per serving
- Why We Love It: Tru Niagen is the gold standard in NAD+ supplementation. It’s backed by over 20 peer-reviewed clinical studies and approved by regulatory bodies in the U.S., Europe, Canada, and Australia. Users consistently report higher energy, clearer thinking, and better overall vitality.
- Unique Benefit: Boosts NAD+ levels by up to 50% within 2 weeks.
- Price: ~$39/month
- Link: truniagen.com
We personally appreciate how consistent Tru Niagen is. You feel the difference—and you know it’s working.
🧬 2. Elysium Basis
Best For: Cellular health + antioxidant support
- Key Ingredients: NR + Pterostilbene
- Why We Love It: This isn’t just a supplement—it’s a scientifically designed NAD+ program. Developed by scientists at MIT, Basis pairs NR with pterostilbene, a powerful antioxidant that works synergistically to support DNA integrity and slow cellular aging.
- Unique Benefit: Enhances NAD+ while also providing long-term protection against oxidative stress.
- Price: ~$49/month
- Link: elysiumhealth.com
We love how smartly formulated this is. You’re not just boosting NAD+, you’re protecting the body on a cellular level.
🚀 3. Renue by Science
Best For: Flexible delivery formats + advanced bioavailability
- Key Ingredients: NMN and NR (various options)
- Why We Love It: Renue by Science offers one of the most customizable NAD+ ranges we’ve seen. From liposomal gels to sublingual sprays and powders, this is ideal for anyone who’s serious about absorption and biohacking their way to better health.
- Unique Benefit: Liposomal and sublingual formulas help NAD+ precursors reach your cells more efficiently.
- Price: ~$45–$65/month
- Link: renuebyscience.com
We’re fans of the spray and powder for morning routines. It absorbs fast and feels like you’re giving your body something truly next-level.
💡 4. Life Extension NAD+ Cell Regenerator
Best For: Affordable and effective NR support
- Key Ingredient: Nicotinamide Riboside Chloride
- Why We Love It: This is a clean, no-frills NAD+ booster from one of the most respected supplement brands out there. It’s simple, effective, and perfect for people who are just starting to explore NAD+ support.
- Unique Benefit: Budget-friendly without sacrificing quality.
- Price: ~$23/month
- Link: lifeextension.com
For those of us just dipping our toes into longevity supplements, this is a solid and reliable choice.
🧠5. Thorne ResveraCel
Best For: Anti-aging and heart health
- Key Ingredients: NR, Resveratrol, Quercetin, Betaine
- Why We Love It: Thorne combines some of the best natural compounds for longevity in one powerful capsule. With the synergy of quercetin and resveratrol, you’re supporting NAD+ while also enhancing your body’s antioxidant defenses and cardiovascular function.
- Unique Benefit: NSF Certified for Sport—trusted by athletes.
- Price: ~$48/month
- Link: thorne.com
This one is great for people over 40 who want a holistic approach to aging support—especially if you’re dealing with inflammation or cardiovascular concerns.
💪 6. Double Wood Supplements NMN
Best For: Pure NMN on a budget
- Key Ingredient: Nicotinamide Mononucleotide (NMN)
- Why We Love It: Double Wood offers third-party-tested NMN that’s simple, clean, and affordable. Their product is made in the USA and designed for high stability. It’s a favorite in longevity circles for a reason.
- Unique Benefit: Great for daily energy and immune support.
- Price: ~$39/month
- Link: doublewoodsupplements.com
We’ve heard from many users that this helped with workout recovery and focus, which makes sense given how NMN supports mitochondria.
💧 7. Alive By Science NMN Sublingual Powder
Best For: Fast-acting absorption
- Key Ingredient: NMN (beta-nicotinamide mononucleotide)
- Why We Love It: This innovative powder is designed to dissolve under your tongue—bypassing the gut and getting into your bloodstream quickly. It’s perfect for those who want quick energy or who don’t like swallowing pills.
- Unique Benefit: Sublingual delivery maximizes absorption.
- Price: ~$55
- Link: alivebyscience.com
This one is a game-changer for early risers and busy professionals who need their supplements to kick in fast.
🌱 8. ProHealth NMN Pro 300
Best For: Ultra-pure NMN lovers
- Key Ingredient: Pharmaceutical-grade NMN
- Why We Love It: ProHealth takes purity seriously. Their NMN is tested for quality and stored under cold conditions to ensure freshness. It’s the go-to for many researchers and longevity-focused users who want nothing but the best.
- Unique Benefit: 3rd party tested and temperature-controlled storage.
- Price: ~$60/month
- Link: prohealth.com
For serious NAD+ seekers, this one’s worth every penny. It’s the closest to lab-grade NMN you’ll find on the market.
How to Choose the Right NAD+ Supplement
Not sure where to begin? Here are some things to consider before buying:
- NR or NMN?
- NR has more clinical research and is generally better tolerated.
- NMN may absorb more quickly and works well for people over 40.
- Delivery Type:
- Capsules are convenient.
- Sublingual or liposomal formulas are faster and more bioavailable.
- Synergistic Ingredients:
- Look for combos with resveratrol, quercetin, or betaine for added benefits.
- Your Personal Goals:
- For energy? Try Tru Niagen or Double Wood.
- For aging support? Go with Elysium or Thorne.
- For flexibility? Renue by Science has options for every lifestyle.
Why NAD+ Matters More Than Ever
We’re not just looking to live longer—we want to live better. NAD+ is at the center of that mission. It fuels our cells, powers our metabolism, supports brain health, and even plays a role in fighting inflammation and stress. Restoring NAD+ isn’t a gimmick—it’s a science-backed strategy that more people are embracing every day.
In a world where chronic fatigue, burnout, and premature aging are all too common, boosting your NAD+ might be one of the smartest wellness moves you can make in 2025.